Area under curve and dual wavelength Spectrophotometric methods have been developed for simultaneous estimation of Cetrizine hydrochloride and Phenyelphrine hydrochloride in bulk drug and in pharmaceutical formulation. All these methods utilizes water as a solvent. In Area Under Curve the wavelength ranges of 225-235nm and 267-277nm were selected as analytical wavelength ranges for the determination of area of both the drugs in pure and in combined formulation. In Dual wavelength method, the absorbance difference was determined within 233nm and 254nm for the the determination of Cetrizine hydrochloride, and absorbance difference within 250nm and 265nm for the determination of Phenylephrine hydrochloride. The results of analysis of all methods have been validated statistically. Lower value of % RSD indicates that these methods were simple, rapid and accurate, hence can be used for routine simultaneous estimation of these drugs in formulations. The results were found to be within acceptance criteria according to ICH Q2 R1 guideline.
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